What is cychlorphine? Synthetic opioid 10 times stronger than fentanyl popping up in multiple states


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Health and law enforcement officials across the country have been sounding the alarm on newer drugs that were increasingly detected in 2025.

WASHINGTON — A powerful synthetic opioid estimated to be 10 times stronger than fentanyl has been surfacing in multiple states, contributing to overdose deaths. 

Cychlorphine has been linked to a growing number of fatal overdoses in several states. In one Tennessee county, the drug has been linked to 50 suspected overdose deaths in the last year, according to Knox County officials. The number of suspected overdose deaths linked to cychlorphine has risen rapidly in recent months. 

When Knox County officials first publicly warned about the drug in February, it had been associated with 16 deaths. By April, the Knox County District Attorney ...

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